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Theses

This page lists all theses written by students working at the research group. Lists of publications and posters are also provided.

Identification of novel inhibitors of target proteins from Plasmodium falciparum.
Peilin Tu completed the Bachelor of Science thesis on June 1, 2017 advised by M.Sc. Mehrosh Pervaiz and M.Sc. Pankaj Mishra and evaluated by Prof. Dr. Stefan Günther
Identification and model‐based optimization of BRPF1 inhibitors.
Yuan Ni completed the M.Sc. thesis on Aug. 1, 2016 advised by M.Sc. Mehrosh Pervaiz and evaluated by Prof. Dr. Stefan Günther and Prof. Dr. Oliver Einsle
Protein-interacting drugs: An exploration of the potential of fragment-based target prediction
Laura van Hazendonk completed the Bachelor thesis on July 5, 2016 advised by M.Sc Kiran Telukunta and evaluated by Prof. Dr. Stefan Günther
Fragmentbasierte Analyse von Struktur-Wirkungsbeziehungen kleiner Moleküle
Moritz Konrad completed the Bachelor thesis on June 15, 2016 advised by M.Sc Kiran Telukunta and evaluated by Prof. Dr. Stefan Günther
Evaluation verschiedener Prozessierungsmethoden für die Auswertung von DNA-Methylierungsdaten unterschiedlicher Zelltypen mithilfe der Plattform Infinium HumanMethylation450
M.Sc Stephan Flemming completed the Ph.D thesis on April 28, 2016 advised by Prof. Dr. Stefan Günther and evaluated by Prof. Dr. Stefan Günther
Integrierte bioinformatische Methoden zur reproduzierbaren und transparenten Hochdurchsatz-Analyse von Life Science Big Data
Björn Grüning completed the Ph.D thesis on Oct. 31, 2015 advised by Prof. Dr. Stefan Günther and evaluated by Prof. Dr. Stefan Günther & Prof. M.Müller
Strukturbasierte in silico-Identifizierung vorhergesagter Polyketide produziert von modularen Typ I-Polyketidsynthasen
Dimitar Yonchev completed the Dipl.-Pharm thesis on Oct. 29, 2015 advised by Jun.-Prof. Dr. Stefan Günther and evaluated by Jun.-Prof. Dr. Stefan Günther & Prof. Dr. Andreas Bechthold
Implementierung eines Analyseschemas für die Auswertung von DNA-Methylierungsdaten in Galaxy und Anwendung auf einen Datensatz mit rezidiven CLL-Zellen nach FCR-Therapie
Simon Bohleber completed the Master of Science thesis on Sept. 21, 2015 advised by M.Sc. Stephan Flemming and evaluated by Jun.-Prof. Dr. Stefan Günther
Identification of new inhibitors of BRWD3
Anika Nietzer completed the Bachelor of Science thesis on Aug. 27, 2015 advised by M.Sc. Mehrosh Pervaiz and evaluated by Jun.-Prof. Dr. Stefan Günther
Untersuchung der strukturellen Diversität von Naturstoffen aus Streptomyces spec
Sören Jahn completed the BSc Pharm thesis on July 31, 2015 advised by M.Sc. Xavier Lucas and evaluated by Jun.-Prof. Dr. Stefan Günther & Prof. Dr. Andreas Bechthold
Extraction of Compound-Protein Interactions from PubMed Using the All-Paths Graph Kernel
Elham Abbasian completed the Master of Science thesis on April 20, 2015 advised by M.Sc. Kersten Döring and evaluated by Jun.-Prof. Dr. Stefan Günther & Prof. Dr. Rolf Backofen
Phylogenetische Klassifizierung von Antibiotika-produzierenden Streptomyceten-Stämmen
Alina Ostendorf completed the BSc Pharm thesis on Feb. 15, 2015 advised by Dipl.-Pharm. Dennis Klementz and evaluated by Jun.-Prof. Dr. Stefan Günther & Prof. Dr. Andreas Bechthold
Discovery of small molecules modulating protein-protein interactions
M.Sc Xavier Lucas completed the Ph.D thesis on Oct. 31, 2014 advised by Jun.-Prof. Dr. Stefan Günther and evaluated by Jun.-Prof. Dr. Stefan Günther & Prof. Dr. Manfred Jung
Entwicklung einer Software zur Unterstützung der strukturbasierten Wirkstofffindung gegen Bromodomänen
Lucas Paetow completed the Bachelor of Science thesis on Sept. 29, 2014 advised by Jun.-Prof. Dr. Stefan Günther and evaluated by Jun.-Prof. Dr. Stefan Günther & Prof. Dr. Oliver Einsle
Experimentelle Validierung der metabolischen Modells des Antibiotika produzierenden Streptomyces sp. Tü6071
Julian Schill completed the Bachelor of Science thesis on July 25, 2014 advised by Dipl.-Pharm. Dennis Klementz and evaluated by Jun.-Prof. Dr. Stefan Günther & Prof. Dr. Andreas Bechthold
ModPKSFinder - towards in silico discovery of novel polyketides
Natalia Padilla completed the Master of Science thesis on July 1, 2014 advised by Jun.-Prof. Dr. Stefan Günther and evaluated by Jun.-Prof. Dr. Stefan Günther
Pharmakophor-basierte Suche nach neuen Inhibitoren von CREBBP
Can Bittner completed the Bachelor of Science thesis on Feb. 27, 2014 advised by M.Sc. Xavier Lucas and evaluated by Jun.-Prof. Dr. Stefan Günther & Prof. Dr. Manfred Jung
Automatisierte Identifizierung funktioneller Beziehungen zwischen Kleinmolekülen und Proteinen in Texten
Michael Becer completed the Bachelor of Science thesis on Jan. 27, 2014 advised by M.Sc. Kersten Döring and evaluated by Jun.-Prof. Dr. Stefan Günther & Dr. Martin Mann
Untersuchung des metabolischen Regulationsnetzwerks des Antibiotika produzirenden Streptomyces sp. Tü6071
Dennis Klementz completed the Dipl.-Pharm. thesis on Dec. 3, 2013 advised by Dr. Anika Erxleben and evaluated by Jun.-Prof. Dr. Stefan Günther & Prof. Dr. Andreas Bechthold
Identification of Molecular Descriptors for Toxicity Prediction of Small Molecules
Lina Maren Grüger completed the Bachelor of Science thesis on Nov. 21, 2013 advised by M.Sc. Kersten Döring and evaluated by Jun.-Prof. Dr. Stefan Günther & Dr. Fabrizio Costa
Systembiologische Modellierung des Antibiotika-produzierenden Bakteriums Streptomyces sp. Tü6071
Michael Damrat completed the Bachelor of Science thesis on May 31, 2013 advised by Dr. Anika Erxleben and evaluated by Jun. - Prof. Dr. Stefan Günther & Prof. Dr. Andreas Bechthold
Analyse der Beziehung zwischen DNA Methylierung und Genexpression im humanen Genom
Wilhelm Schulz completed the Bachelor of Science thesis on April 30, 2013 advised by M.Sc. Stephan Flemming and evaluated by Jun.-Prof. Dr. Stefan Günther & Prof. Dr. Manfred Jung
Charakterisierung des chemischen Raums mittels physiko-chemischer Deskriptoren
Stefan Bleher completed the Bachelor of Science thesis on Feb. 1, 2013 advised by M.Sc. Björn Grüning & M.Sc. Xavier Lucas and evaluated by Jun.-Prof. Dr. Stefan Günther & Jun.-Prof. Dr. Jennifer Andexer
Einfluss des DNA-Methylierungsmusters auf die Genregulation der menschlichen Zelle
Simon Bohleber completed the Bachelor of Science thesis on Nov. 30, 2012 advised by M.Sc. Stephan Flemming and evaluated by Jun.-Prof. Dr. Stefan Günther & Prof. Dr. Manfred Jung
Etablierung der Produktion von Phenalinolactonen durch Streptomyces sp. Tü6071 im Bioreaktor
Johannes Mosch completed the Diplom thesis on Nov. 30, 2012 advised by Dr. Anika Erxleben and evaluated by Jun.-Prof. Dr. Stefan Günther & Prof. Dr. Andreas Bechthold
Genomannotation und Charakterisierung des Avilamycin produzierenden Bakteriums Streptomyces viridochromogenes Tü57
Anna Hähnlein completed the Bachelor of Science thesis on June 28, 2012 advised by M.Sc. Björn Grüning and evaluated by Jun. - Prof. Dr. Stefan Günther & Prof. Dr. Andreas Bechthold